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tumor resist  hypoxya p
Hypoxia enhances tumor cell resistance to cell stress by starvation and hypothermia   Since many years ago it is well known that tumor cells cultured in hypoxia conditions show higher survival performances when exposed to radiation and diverse drugs (for example: I. TANNOCK and P. GUTTMAN, 1980, J.M. BROWN 1999). That was observed with certain perplexity because exposure to oxygen is...
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hypoxia 1 s
Culture Hypoxia at Physiologic Oxygen Tension Enhances Cartilage Repair Potential of MSCs   Cartilage is an avascular tissue in which the specific cells (chondrocytes) live in a physiologic oxygen tensions between 7 and 50 mmHg. In this avascular environment, chondrocytes regularly express the dimeric Hypoxia-inducible factor 1 (HIF-1), which regulates cell physiology mediating changes in gene transcription, in response to changes...
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